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lactococcus lactis strain plasma

The first such product, launched in December 2017, is a chewable supplement that can be taken without water. Get the latest public health information from CDC: https://www.coronavirus.gov. The specific LAB strain may affect the anti-viral immunological profile of IECs via maturation of LP pDCs, leading to protection from RV virus infection in vivo. The unique lactic acid bacteria, Lactococcus lactis strain plasma (LC-Plasma), stimulates plasmacytoid dendritic cells, which play an important role in viral infection. Long-term administration of pDC-Stimulative Lactococcus lactis strain decelerates senescence and prolongs the lifespan of mice. https://doi.org/10.1016/j.intimp.2018.01.034. IFN-stimulated genes (ISGs) were up-regulated in the small intestinal epithelial cells (IECs) of LC-Plasma-fed mice. Lactococcus lactis strain Plasma was discovered by our joint team in 2011. In contrast, Lactococcus lactis strain Plasma directly activates pDCs, which act together in the role of "commander in chief" of the immune system. Sugimura T, Jounai K, Ohshio K, Suzuki H, Kirisako T, Sugihara Y, Fujiwara D. Int Immunopharmacol. The Lactococcus lactis strain Plasma is a product of joint research by Kirin Holdings, Koiwai Dairy Products, and Kyowa Hakko Bio, and a number of relevant papers have been published and many presentations have been given at medical societies in cooperation … Get the latest research from NIH: https://www.nih.gov/coronavirus. bacteria) of Lactococcus lactis strain Plasma for 8 weeks from January to March 2017, and their skin condition was evaluated. Responsibility as a pharmaceutical manufacturer, Further information is available in "The Lactococcus lactis strain Plasma anti-viral defense mechanism. lactis JCM 5805 (LC-Plasma) is a strain of lactic acid bacteria (LAB) that activates murine and human plasmacytoid dendritic cells (pDCs) to express interferons (IFNs). 2018 Mar;56:205-211. doi: 10.1016/j.intimp.2018.01.034. Taken together, long-term oral administration of LC-Plasma could prevent immune-senescence and other senescence phenotypes at the organ level. The authors previously reported that LC-Plasma reduced the number of days athletes experienced cold-like symptoms and fatigue feelings after high-intensity exercise training; however, the mechanism was unclear. The expression levels of anti-viral factors induced by IFNs, such as Isg15, Mx1, Oasl2 and Viperin, and an anti-bacterial factor Reg3γ, were up-regulated in the small intestinal epithelial cells (IECs) of LC-Plasma-fed mice. Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of. Related to these phenotypes, the senescence score in the LC-Plasma group was significantly decreased at 47 weeks of age compared with that in the control group. We use cookies to help provide and enhance our service and tailor content and ads. Oral administration of LC-Plasma induced maturation of pDCs in the small intestine. In SAMP10 mice, in addition to preventing a decrease in the naïve T cell ratio, aging-associated skin thinning was suppressed histologically and the expression of representative tight junction genes, such as Claudin-1 and Zo-1, was increased. HHS Lactococcus lactis subsp. COVID-19 is an emerging, rapidly evolving situation. Epub 2019 Jul 18. But conventional lactic acid bacteria can stimulate only a few of these, such as NK cells. 2019;153(4):179-185. doi: 10.1254/fpj.153.179. Oral administration of LC-Plasma drastically decreased fatality levels caused by parainfluenza virus infection in a murine model. [Clinical trial results] The gene expression levels of tight junction*1 and a bactericidal peptide*2, which are essential in maintaining the …  |  * A UNIQUE MECHANISM FOR IMMUNE SUPPORT: By activating pDC, LC Plasma activates the entire defense system when it’s needed most. This greatly increases the anti-viral potential of the peripheral immune function. 2018 Oct 1;111:10-16. doi: 10.1016/j.exger.2018.06.028. Based on expert opinion and the scientifically verified efficacy of Lactococcus lactis strain Plasma, we have also begun promoting it through specialists advising those with elevated health concerns — such as the elderly and parents of small children. This is the only lactic acid bacterium that has been confirmed to directly activate Plasmacytoid dendritic cells (pDCs) — which together act as the "commander in chief" of the immune system. In this study, we investigated the effect of long-term oral administration of LC-Plasma on IFN-α induction activity and individual senescence in the senescence-accelerated mice strains Prone 1 (SAMP1) and Prone 10 (SAMP10). Sugimura T, Jounai K, Ohshio K, Fujiwara D. Biosci Biotechnol Biochem. Jounai K, Sugimura T, Morita Y, Ohshio K, Fujiwara D. Int Immunopharmacol. Koiwai, Kirin Beverages, and Kyowa Hakko Bio have rolled out products incorporating Lactococcus lactis strain Plasma in the yoghurt (probiotic drink), soft drink, and dietary supplement categories, respectively. IFN-α; Individual senescence; LC-Plasma; SAM. Lactococcus lactis subsp. 2019 Nov;83(11):2140-2143. doi: 10.1080/09168451.2019.1642098. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. © 2018 Elsevier B.V. All rights reserved. Kirin Group companies are applying the fruits of this research to their businesses. Therefore, LC-Plasma is suggested to be a useful functional food material for decelerating individual senescence. 2009 Apr;34(4):639-59. doi: 10.1007/s11064-009-9922-y. Neurochem Res. Based on its scientific studies, this joint R&D team applies its findings to the development of food products for healthy living. Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence. In this study, we investigated the anti-viral effects of oral administration of LC-Plasma using a suckling mouse model of rhesus rotavirus (RV) infection. Meanwhile, we are educating the public about Lactococcus lactis strain Plasma. This site needs JavaScript to work properly. Aging is accompanied by the decline in immune function, resulting in increasing susceptibility to infectious diseases and tumorigenesis. Exp Gerontol. This is the only lactic acid bacterium that has been confirmed to directly activate Plasmacytoid dendritic cells (pDCs) — which together act as the "commander in chief" of the immune system. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. However, the effects of long-term administration of LC-Plasma are not known. Lactococcus lactis subsp. Nutrients. LC-Plasma is the dietary ingredient that offers a more comprehensive approach to support immune health. Oral administration of LC-Plasma drastically decreased fatality levels caused by parainfluenza virus infection in a murine model. Diet and Skin Aging-From the Perspective of Food Nutrition. Copyright © 2018 Elsevier Inc. All rights reserved. Health-supporting food products based on scientific research. Lactococcus lactis strain Plasma was discovered by our joint team in 2011. In addition, we have developed products specifically to be marketed through healthcare professionals, including doctors, pharmacists, nurses and nutritionists. The mechanism of anti-viral effects elicited by LC-Plasma administration was investigated using naive mice: in the LC-Plasma -fed mice, lamina propria (LP) pDCs resident in the small intestine were significantly matured and the proportion of pDCs was increased. Lactococcus lactis strain Plasma (LC-Plasma) is a clinically researched strain of lactic acid bacterium. These articles have been cited frequently by other researchers in their own research papers. Epub 2018 Jun 30. ", CASE1 Kirin Ichiban Shibori Relaunch and Craft Beer Market Development, CASE2 Pharmaceuticals for Worldwide Markets, CASE3 Lactococcus lactis strain Plasma Stars in New Products, CASE4 Advanced High-Efficiency Facilities at Myanmar Brewery.

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